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ACROBiosystems Human B7-H4 2Vials
Supplier: ACROBiosystems CHEKATP1262VIALS
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4 Protein B7S1 T-cell costimulatory molecule B7x B7H4 which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation proliferation cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
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