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  4. Gibco™ Human BMP-4 Recombinant Protein 

Gibco™ Human BMP-4 Recombinant Protein

Catalog No. PHC9534
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Quantity:
1 mg
10 μg
100 μg

Description

Recombinant Protein

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute lyophilized recombinant human BMP-4 in 4 mM HCl containing 0.1% human serum albumin. Further dilutions should be made in low endotoxin medium or a buffered solution containing a carrier protein such as heat inactivated FCS or tissue culture grade BSA. Storage: Store this lyophilized preparation at =-20°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at =-20°C. Avoid repeated freeze/thaw cycles.

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P12644, P21275
For Use With (Application) Control, ELISA, Functional Assay, Western Blot
Formulation HCl with no preservative
Gene ID (Entrez) 12159, 652
Molecular Weight (g/mol) 34 kDa
Name Human BMP-4
Purification Method Gel-Purified
Quantity 10 μg
Endotoxin Concentration <1 EU/μg
Gene Alias BMP; BMP2B; BMP-2 B; Bmp2b1; Bmp2b-1; Bmp4; Bmp-4; BOMPR4A; Bone morphogenetic protein; Bone morphogenetic protein 2 B; bone morphogenetic protein 4; bone morphogenetic protein 4 preproprotein; DVR4; Dvr-4; MCOPS6; OFC11; ZYME
Common Name BMP4
Biological Activity ED50 = 2 - 10 ng/mL; determined by the dose-dependent induction of alkaline phosphatase production in ATDC-5 cells.
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Content And Storage -20°C
Classification Carrier-Free
Activity 2 ng/ml
Bioassay Induction of alkaline phosphatase in ATDC5 cells
Endotoxin Level <1 EU/ml
Shipping Condition Dry Ice
Expression System HEK293 cells
Protein Family Growth Factors & Receptors
Protein Form Recombinant, Ligand
Form Lyophilized
Protein Subtype BMPs (Bone Morphogenetic Proteins) & Related Factors
Research Category Bone Research, Stem Cell Research, Differentiation
Product Line Gibco™
Purity or Quality Grade >95% by SDS-PAGE
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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