Invitrogen™ Human Caspase 4 (aa 14-107) Control Fragment Recombinant Protein

Catalog No.	Quantity
RP95147	100 μL

Catalog No. RP95147 Supplier Invitrogen™ Supplier No. RP95147

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (46%), Rat (46%). This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Specifications

• Accession Number: P49662
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Neutralization, Control
• Formulation: PBS, 1M urea with no preservative; pH 7.4
• Gene ID (Entrez): 837
• Name: Human Caspase 4 (aa 14-107) Control Fragment
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 100 μL
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: apoptotic cysteine protease Mih1/TX; Casp11; CASP-11; CASP4; CASP-4; caspase 11; caspase 4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis-related cysteine protease; Caspase-11; Caspase-4; Caspase-4 subunit 1; Caspase-4 subunit 2; Caspase-4 subunit p10; Caspase-4 subunit p20; Caspl; ICE and Ced-3 homolog 2; ICE(rel)II; ICE(rel)-II; ICEREL-II; ICH2; ICH-2; Ich3; ich-3; Mih1; Mih1/TX; protease ICH-2; Protease ICH-3; Protease TX; TX
• Common Name: Caspase 4
• Gene Symbol: CASP4
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: LESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALK
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining