Invitrogen™ Human CCL3 (MIP-1 alpha) Recombinant Protein

Catalog No.	Quantity
PIRP10923	20 μg

Catalog No. PIRP10923 Supplier Invitrogen™ Supplier No. RP10923

Description

Recombinant Protein

The RP-10923 protein is a recombinant protein suitable for use as a control in ELISA and Western blot applications. Reconstitute the lyophilized product in sterile water not less than 100 μg/mL.

Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1alpha and MIP-1beta exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes, and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells.

Specifications

• Accession Number: P10147
• For Use With (Application): Control
• Formulation: protein with no preservative
• Gene ID (Entrez): 6348
• Molecular Weight (g/mol): 7.8 kDa
• Name: Human CCL3 (MIP-1 alpha)
• Quantity: 20 μg
• Source: E. coli
• Immunogen: N/A
• Regulatory Status: RUO
• Gene Alias: AI323804; C-C motif chemokine 3; C-C motif chemokine ligand 3; CCL3; chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; G0S19-1; Heparin-binding chemotaxis protein; H-MIP-1-alpha; L2G25B; LD78ALPHA; LD78-alpha; LD78-alpha(4-69); Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); macrophage inflammatory protein 1-alpha; macrophage inflammatory protein-1 alpha; MIP1 (a); mip1 alpha; MIP-1 alpha; MIP1-(a); MIP1A; MIP-1 A; MIP-1 alpha; MIP-1-alpha; MIP1-alpha; MIP-1-alpha(4-69); PAT 464.1; RP23-320E6.7; Scya3; SIS-alpha; SIS-beta; small inducible cytokine A3; small inducible cytokine A3 (homologous to mouse Mip-1 A); small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein; TY-5
• Common Name: CCL3 (MIP-1 alpha)
• Gene Symbol: CCL3
• Biological Activity: ED50 = 0.2 nM; determined by the dose-dependent chemotaxis of recombinant CCR5-expressing cells.
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Sequence: Human CCL3 recombinant protein contains 70 amino acids
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Lyophilized
• Protein Subtype: Recombinant

Safety and Handling

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