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Invitrogen™ Human CDK4 Recombinant Protein

Catalog No. PIRP75530
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PIRP75530 10 μg
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Catalog No. PIRP75530 Supplier Invitrogen™ Supplier No. RP75530
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Description

Recombinant Protein

This product contains purified recombinant human CDK4 protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.

CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P11802
Concentration 0.081 mg/mL
For Use With (Application) Control, Western Blot
Formulation 0.01 M Bis-tris propane with 0.1 M NaCl, 50% glycerol and no preservative; pH 9.0
Gene ID (Entrez) 1019
Molecular Weight (g/mol) 38 kDa
Name Human CDK4
pH Range 9.0
Quantity 10 μg
Source E. coli
Immunogen N/A
Regulatory Status RUO
Gene Alias Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903)
Common Name CDK4
Gene Symbol CDK4
Conjugate Unconjugated
Species E. coli
Recombinant Recombinant
Protein Tag His-tag
Sequence Amino acids Met1- Glu303 containing an N-terminal His-tag
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Protein Subtype Recombinant
Purity or Quality Grade >95%, by SDS-PAGE under reducing conditions
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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