Invitrogen™ Human CELSR1 (aa 2710-2799) Control Fragment Recombinant Protein

Catalog No.	Quantity
RP107013	100 μL

Catalog No. RP107013 Supplier Invitrogen™ Supplier No. RP107013

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (74%), Rat (74%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-111506. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

CELSR1 is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor like repeats and two laminin A G type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact mediated communication, with cadherin domains acting as homophilic binding regions and the EGF like domains involved in cell adhesion and receptor ligand interactions. This particular member is a developmentally regulated, neural specific gene which plays an unspecified role in early embryogenesis.

Specifications

• Accession Number: Q9NYQ6
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Neutralization, Control
• Formulation: PBS, 1M urea with no preservative; pH 7.4
• Gene ID (Entrez): 9620
• Name: Human CELSR1 (aa 2710-2799) Control Fragment
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 100 μL
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: ADGRC1; adhesion G protein-coupled receptor C1; cadherin EGF LAG seven-pass G-type receptor 1; Cadherin family member 9; cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila); CDHF9; CELSR1; Flamingo homolog 2; FMI2; hFmi2; ME2; protocadherin flamingo 2
• Common Name: CELSR1
• Gene Symbol: CELSR1
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: KHLKGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQKLGVSSGLVRGSHGEPDASLMPRSCKD
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining