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Invitrogen™ Human Complement C4 ELISA Kit

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Quantity:
96 Tests
Description
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.

Specifications
Specifications
Accession Number | P0C0L4, P0C0L5 |
Assay Range | 3.13 to 200 ng/mL |
Assay Sensitivity | 1.88 ng/mL |
Conjugate | HRP |
Product Type | ELISA |
Sample Type | Plasma, Serum |
For Use With (Equipment) | Colorimetric Microplate Reader |
Gene ID (Entrez) | 100293534, 720, 721 |
Gene Symbol | C4A, C4B |
Interassay CV | <10% |
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