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Invitrogen™ Human Complement C4 ELISA Kit

Catalog No. EEL075
Encompass_Preferred
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Quantity:
96 Tests

ELISA

This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P0C0L4, P0C0L5
Assay Range 3.13 to 200 ng/mL
Assay Sensitivity 1.88 ng/mL
Conjugate HRP
Product Type ELISA
Sample Type Plasma, Serum
For Use With (Equipment) Colorimetric Microplate Reader
Gene ID (Entrez) 100293534, 720, 721
Gene Symbol C4A, C4B
Interassay CV <10%
Intraassay CV <10
Kit Contents Pre-coated 96 well plate, Standard, Biotinylated Detection Antibody, HRP Conjugate, Standard & Sample Diluent, Biotinylated Detection Antibody Diluent, HRP Conjugate Diluent, Wash Buffer, TMB Substrate, Stop Solution, Plate Sealer
Label or Dye HRP
Quantity 96 Tests
Regulatory Status RUO
Sample Volume Plasma 100 μL, Serum 100 μL
Storage Requirements Refer to product documentation for component specific storage temperature.
Target Complement C4
Test Time 1 hrs 20 mins
Total Assay Time 3 hrs 30 mins
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