Invitrogen™ Human FBXL20 Synthetic Peptide

Catalog No.	Quantity
PEP0606	50 μg

Catalog No. PEP0606 Supplier Invitrogen™ Supplier No. PEP0606

Description

Synthetic Peptide

This peptide corresponds to 18 amino acids near the amino terminus of human SCRAPPER. PEP-0606 can be used as a blocking peptide with polyclonal antibody PA5-20486.

Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.

Specifications

• Gene ID (Entrez): 84961
• Species: Human
• Purification Method: purified
• Accession Number: Q96IG2
• Common Name: FBXL20
• Concentration: 200 μg/mL
• Content And Storage: -20°C
• Description: Synthetic Peptide
• Format: Liquid
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
• For Use With (Application): Blocking Assay, Control
• Gene Alias: 2610511F20Rik; 4632423N09Rik; AI849362; AL117906; C86145; Fbl2; Fbl20; F-box and leucine rich repeat protein 20; F-box and leucine-rich repeat protein 20; F-box protein FBL2; F-box/LRR-repeat protein 20; F-box/LRR-repeat protein 2-like; Fbxl2; Fbxl20; mKIAA4147; Scr; scrapper
• Gene Symbol: FBXL20
• Lyophilized: No
• Preservative: Sodium azide
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Storage Buffer: PBS