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Invitrogen™ Human FRMPD4 Synthetic Peptide

Catalog No. PEP0955 Shop All Thermo Scientific Products
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Catalog No. Quantity
PEP0955 50 μg
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Catalog No. PEP0955 Supplier Invitrogen™ Supplier No. PEP0955
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Description

Synthetic Peptide

This peptide corresponds to 18 amino acids near the center of human of FRMPD4. PEP-0955 can be used as a blocking peptide with polyclonal antibody PA5-20841.

The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD4, also known as Preso, also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus. It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions. Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width; conversely, knockdown experiments using RNAi caused a decrease in spine density, indicating FRMPD4 positively regulates dendritic spine density but not morphology. The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission, suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission.
TRUSTED_SUSTAINABILITY

Specifications

Gene ID (Entrez) 9772
Species Human
Purification Method purified
Accession Number Q14CM0
Common Name FRMPD4
Concentration 200 μg/mL
Content And Storage -20°C
Description Synthetic Peptide
Format Liquid
Formulation PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
For Use With (Application) Blocking Assay, Control
Gene Alias FERM and PDZ domain containing 4; FERM and PDZ domain-containing protein 4; FRMPD4; KIAA0195; KIAA0316; PDZ domain-containing protein 10; PDZD10; PDZK10; Preso; PSD-95-interacting FERM and PDZ domain protein; PSD-95-interacting regulator of spine morphogenesis; TMEM94; Transmembrane protein 94
Gene Symbol FRMPD4
Lyophilized No
Preservative Sodium azide
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO
Storage Buffer PBS
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