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Gibco™ Human GDNF Recombinant Protein

Catalog No. PHC7041
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Catalog No. Quantity
PHC7041 100 μg
50-254-4947 1 mg
PHC7044 5 μg
PHC7045 10 μg
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Catalog No. PHC7041 Supplier Gibco™ Supplier No. PHC7041
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Description

Recombinant Protein

Carrier-Free Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute lyophilized human GDNF in sterile, distilled water to 0.1-0.5 mg/mL. These stock solutions should be apportioned into working aliquots and stored at ≤-20°C. Further dilution should be made in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Lyophilized human GDNF should be stored at 2°C to 8°C, preferably desiccated. Store reconstituted human GDNF at ≤-20°C (not in a frost-free freezer). Keep freeze-thaw cycles to a minimum.

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
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Specifications

Accession Number P39905
For Use With (Application) Bioactivity
Formulation Protein with no preservative
Gene ID (Entrez) 2668
Molecular Weight (g/mol) 30.1 kDa
Name Human GDNF
Purification Method Purified
Quantity 100 μg
Storage Requirements 4°C
Regulatory Status RUO
Endotoxin Concentration <0.1 ng/μg
Gene Alias AI385739; Astrocyte-derived trophic factor; ATF; ATF1; ATF2; Gdnf; glial cell derived neurotrophic factor; glial cell line derived neurotrophic factor; Glial cell line derived neutrophic factor; glial cell line-derived neurotrophic factor; gndf; HFB1-GDNF; hGDNF; H-GDNF; HSCR3; mGDNF; neurotrophic factor
Common Name GDNF
Gene Symbol GDNF
Biological Activity ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Sequence SPDKQMAVLP RRERNRQAAA ANPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCDAAETTYD KILKNLSRNR RLVSDKVGQA CCRPIAFDDD LSFLDDNLVY HILRKHSAKR CGCI
Content And Storage 4°C
Classification Carrier-Free
Activity ED50 ≤ 10 n/mL; determined by the dose-dependent neurite outgrowth of PC-12 cells in the presence of soluble GFR-alpha.
Endotoxin Level <0.1 ng/μg
Shipping Condition Approved for shipment on Wet or Dry Ice
Expression System E. coli
Protein Family Growth Factors & Receptors
Protein Form Recombinant, Ligand
Form Lyophilized
Protein Subtype Neurotrophic Factors
Research Category Neurobiology, Stem Cell Research, Differentiation
Product Line Gibco
Purity or Quality Grade >98% by SDS-PAGE
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Safety and Handling

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