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Medchemexpress LLC Human GIP(3-30), amide | 1884226-05-4 | 99.8% | 3297.69 | 5 MG
SDP

Supplier:  Medchemexpress LLC HYP101385MG

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Human GIP(3-30), amide is a high-affinity antagonist of the human GIP receptor in vitro. It is being investigated for its potential anti-obesity and anti-diabetic effects.

  • High affinity antagonist: Competitively binds to the GIP receptor (GIPR), blocking GIP-mediated cAMP accumulation (Ki=16.8 nM), β-arrestin recruitment (Ki for β-arrestin-1/2 recruitment is 10.6 nM and 10.2 nM), and receptor internalization.
  • Inhibits insulin secretion: It has been shown to inhibit GIP-mediated insulin secretion and signal transduction in adipocytes.
  • Selective for human GIP receptor: This compound demonstrates high-affinity binding to primate GIP receptors but not rodent GIP receptors.
  • Research use only: This product is intended solely for research purposes and is not for sale to patients.

Catalog No. 50-004-24057


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