Invitrogen™ Human Glucocorticoid Receptor (aa 346-367) Synthetic Peptide

Catalog No.	Quantity
PEP001	50 μg

Catalog No. PEP001 Supplier Invitrogen™ Supplier No. PEP001

Description

Synthetic Peptide

PEP-001 is a 22 amino acid (amino acids 346-367) synthetic peptide whose sequence is from the amino terminus of the human glucocorticoid receptor (GR). The sequence of this peptide is (amino to carboxy terminus): D-Q-K-P-I-F-N-V-I-P-P-I-P-V-G-S-E-N-W-N-R-C (The C-terminal cysteine has been added to facilitate conjugation and is not a part of the native human GR sequence) This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the human GR, catalog # PA1-511A. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody. Reconstitute with 0.1 mL of distilled water.

Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity.

Specifications

• Gene ID (Entrez): 2908
• Species: Human
• Purification Method: purified
• Accession Number: P04150
• Common Name: Glucocorticoid Receptor (Nr3c1)
• Concentration: 0.5 mg/mL
• Content And Storage: -20°C. Avoid freeze-thaw cycles.
• Description: Synthetic Peptide
• Format: Lyophilized
• Formulation: Peptide with no preservative
• For Use With (Application): Control
• Gene Alias: cytosolic/nuclear receptor; fb13f09; GCCR; Gcr; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor alpha; GR; gr alpha; GR Kit; Grl; Grl1; Grl-1; Nr3c1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; utouto; utut; wu:fb13f09; zgc:113038
• Gene Symbol: Nr3c1
• Lyophilized: Yes
• Preservative: No preservative
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Sequence: D - Q - K - P - I - F - N - V - I - P - P - I - P - V - G - S - E - N - W - N - R - C