Invitrogen™ Human HDAC3 (aa 415-428) Synthetic Peptide

Catalog No.	Quantity
PEP071	50 μg

Catalog No. PEP071 Supplier Invitrogen™ Supplier No. PEP071

Description

Synthetic Peptide

PEP-071 is a 15 amino acid synthetic peptide whose sequence corresponds to residues 415-428 of human HDAC 3 with an amino terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): C-D415-G-D-H-D-N-D-K-E-S-P-V-E-I428 This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human HDAC 3, catalog # PA1-862. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 50 μL of distilled water for a concentration of 1 mg/mL.

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

Specifications

• Gene ID (Entrez): 8841
• Species: Human
• Purification Method: purified
• Accession Number: O15379
• Common Name: HDAC3
• Concentration: 1 mg/mL
• Content And Storage: -20°C. Avoid freeze-thaw cycles.
• Description: Synthetic Peptide
• Format: Lyophilized
• Formulation: Peptide with no preservative
• For Use With (Application): Control
• Gene Alias: AW537363; HD3; Hdac3; HDAC3 splicing HDAC3alpha; HDAC3 splicing HDAC3beta; HDAC3 splicing HDAC3delta; HDAC3 splicing HDAC3gamma; histone deacetylase 3; histone deacetylase 3-like protein; RPD3; RPD3-2; SMAP45
• Gene Symbol: HDAC3
• Lyophilized: Yes
• Preservative: No preservative
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Sequence: C - D415 - G - D - H - D - N - D - K - E - S - P - V - E - I428