Invitrogen™ Human IFN-alpha 2 (alpha 2b) Recombinant Protein

Catalog No.	Quantity
PI111051	1 x 10^5 units

Catalog No. PI111051 Supplier Invitrogen™ Supplier No. 111051

Description

Recombinant Protein

After receipt, the product may be stored at -20°C for short-term use (less than 6 months). For long-term storage, store the product at -70°C or below for retention of full activity. Thaw product vial by incubation in cold tap water until just thawed. Aliquot and refreeze unused contents to minimize effects of freeze thawing. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of product should be in buffers containing protein such as 0.1% BSA or tissue culture media with serum.

Interferon alpha-2b is a cytokine that belongs to the type I interferon family and is encoded by a gene cluster on chromosome 9. It is produced in response to viral infection and plays a key role in the innate immune response, exhibiting potent antiviral, antiproliferative and immunomodulatory properties. Interferon alpha-2b binds to a plasma membrane receptor consisting of IFNAR1 and IFNAR2, which is expressed ubiquitously in the body and can thus act on virtually all cells. This cytokine is effective in reducing the symptoms and duration of the common cold, and has shown efficacy in treating various types of cancer, including hematological malignancies and solid tumors. A deficiency of type I interferon in the blood is considered a hallmark of severe COVID-19, and a combination therapy involving interferon alpha-2b may be a potential therapeutic approach. IFNA2 has been associated with diseases such as Severe Covid-19 and Hepatitis B.

Specifications

• Accession Number: P01563
• Concentration: Lot-specific
• For Use With (Application): ELISA
• Formulation: PBS with 0.1% BSA and no preservative
• Gene ID (Entrez): 3440
• Molecular Weight (g/mol): 19.3 kDa
• Name: Human IFN-alpha 2 (alpha 2 b)
• Quantity: 1 x 10^5 units
• Source: E. Coli
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: alpha-2 A interferon; IFNA; IFNA2; IFNA2A; IFNA2B; IFNA2C; IFN-alpha-2; IFN-alphaA; INFA2; Interferon; interferon alpha 2; interferon alpha 2 A; interferon alpha 2 b; interferon alpha A; interferon alpha-2; Interferon alpha-A; interferon, alpha 2; leIF A
• Common Name: Interferon alpha-2 b
• Gene Symbol: IFNA2
• Biological Activity: EC50 ̃ 1 U/mL; determined by use of the cytopathic effect inhibition assay described in [Rubinstein, S. et al. (1981). J. Virol. 37, 755-758 ]; [Familletti, P.C. et al. (1981). Methods in Enzymology, Vol. 78, 387-394 ]. The units are determined with respect to the international reference standard for human interferon alpha A (Hu-IFN-alpha-A) provided by the National Institutes of Health [see Pestka, S. (1986). Methods in Enzymology, Academic Press, New York 119, 14-23 ]. Unit of activity measured on bovine MDBK cells with vesicular stomatitis virus (VSV).
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Protein Subtype: Recombinant
• Purity or Quality Grade: >95%

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov