Gibco™ Human IFN-beta 1a Recombinant Protein

Catalog No.	Quantity
PHC4244	1 x 10^5 units

Catalog No. PHC4244 Supplier Gibco™ Supplier No. PHC4244

Description

Recombinant Protein

Source: cDNA obtained from human fibroblast interferon beta 1a mRNA expressed in CHO cells. Storage: After receipt, the product may be stored at -20°C for short-term use (<6 months). For long-term storage, store the product at -70°C or below for retention of full activity. Thaw product vial by incubation in cold tap water until just thawed. The contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

Specifications

• Accession Number: P01574
• For Use With (Application): Bioactivity
• Formulation: 50mM sodium acetate with 0.1% BSA and no preservative
• Gene ID (Entrez): 3456
• Molecular Weight (g/mol): 23 kDa
• Name: Human IFN-beta 1a
• Purification Method: Purified
• Quantity: 1 x 10^5 units
• Storage Requirements: -80°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: beta 1; fibroblast interferon; IFB; IFF; IFNB; IFNB1; IFN-beta; Interferon; Interferon beta; interferon beta 1; Interferon beta-1a; interferon, beta 1, fibroblast; interferon-beta
• Common Name: IFN beta-1a
• Gene Symbol: IFNB1
• Biological Activity: EC50 ̃ 1 U/mL; determined by a cytopathic inhibition assay on human A549 lung carcinoma cells with encephalomyocarditis virus (EMCV).
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Content And Storage: -80°C
• Activity: EC50 ~ 1 U/mL; determined by a cytopathic inhibition assay on human A549 lung carcinoma cells with encephalomyocarditis virus (EMCV).
• Shipping Condition: Dry Ice
• Expression System: CHO cells
• Protein Family: Cytokines & Receptors
• Protein Form: Recombinant, Ligand
• Form: Liquid
• Protein Subtype: Interferons
• Research Category: Immunology, Virology, Angiogenesis
• Product Line: Gibco
• Purity or Quality Grade: >95%

Safety and Handling

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