Invitrogen™ Human IL-13 Recombinant Protein

Catalog No.	Quantity
PIRP88070	1 mg
PIRP88069	100 μg
PIRP88068	5 μg

Catalog No. PIRP88070 Supplier Invitrogen™ Supplier No. RP88070

Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. Reconstitute with sterile deionized water to 0.1 mg/mL. Concentration is measured by UV.

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.

Specifications

• Accession Number: P35225
• Concentration: 0.25 mg/mL
• For Use With (Application): Control, Bioactivity
• Format: Lyophilized
• Formulation: PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
• Gene ID (Entrez): 3596
• Molecular Weight (g/mol): 12.35 kDa
• Name: Human IL-13
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 1 mg
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Endotoxin Concentration: <0.01 EU/μg
• Gene Alias: ALRH; ALRH antibody; BHR1; il 13; Il13; Il-13; IL-13; cytokine; ILN; Interleukin; interleukin 13; Interleukin13; interleukin-13; interleukin-13 precursor; L13; MGC116786; MGC116788; MGC116789; NC30; NC30 antibody; P600; P600 antibody; T-cell activation protein P600
• Common Name: IL-13
• Gene Symbol: Il13
• Biological Activity: Measured in a cell proliferation assay using TF1 human erythroleukemic cells (Kitamura, T. et al. 1989, J. Cell Physiol. 140:323.). The ED50 for this effect is typically 0.5-3 ng/mL
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: Human IL13, amino acids Met1-Asn132 (Accession # AAK53823.1)
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Activity: Measured in a cell proliferation assay using TF1 human erythroleukemic cells (Kitamura, T. et al. 1989, J. Cell Physiol. 140:323.). The ED50 for this effect is typically 0.5-3 ng/mL.
• Expression System: CHO cells
• Form: Lyophilized
• Purity or Quality Grade: ≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC