Invitrogen™ Human IL-2 Recombinant Protein

Catalog No.	Quantity
50-926-1	50 μg

Catalog No. 50-926-1 Supplier Invitrogen™ Supplier No. BMS334

Description

Recombinant Protein

Description: Recombinant human IL-2 produced in E.Coli is a single, non-glycosylated mutein (variant form) of human IL-2 polypeptide chain containing 133 amino acids and having a molecular mass of 15385.79 Dalton. eBioscience's rhIL-2 is Des N-Terminal Met and has an Ala substitute for Cysteine at position 126. BMS334 is fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is <0.0645 ng/mL, corresponding to a specific activity of 1.55x107 IU/mg. Purity: >99%. Molecular Weight: 15.4 kDa.

Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.

Specifications

• Accession Number: P60568
• For Use With (Application): Neutralization
• Formulation: Protein with no preservative
• Gene ID (Entrez): 3558
• Molecular Weight (g/mol): 15.4 kDa
• Name: Human IL-2
• Purification Method: Purified
• Quantity: 50 μg
• Source: E. coli
• Storage Requirements: 4°C
• Regulatory Status: RUO
• Gene Alias: aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
• Common Name: IL-2
• Gene Symbol: IL2
• Biological Activity: ED50 < 0.0645 ng/mL; determined by dose-dependent stimulation of murine CTLL-2 cells. This corresponds to a specific activity of 1.55 x 10e7 IU/mg.
• Product Type: Protein
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Sequence: Human IL-2 recombinant protein contains 133 amino acids. It contains and N-terminal Met and a A126C substitution.
• Content And Storage: 4°C
• Activity: ED50 < 0.0645 ng/mL; determined by dose-dependent stimulation of murine CTLL-2 cells. This corresponds to a specific activity of 1.55x10e7 IU/mg.
• Expression System: E. coli
• Form: Lyophilized
• Protein Subtype: Recombinant
• Purity or Quality Grade: >99%

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov