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Invitrogen™ eBioscience™ Human IL-23 Platinum ELISA Kit Non-distribution product as customer accommodation.

Engineered for accurate and precise measurement of IL-23 protein levels from samples including serum, plasma and cell culture supernatants. The use of a p19-specific capture antibody and a p40-specific detection antibody renders this sandwich ELISA exquisitely specific for human IL-23.

Manufacturer:  Invitrogen™ BMS20233

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Catalog No. 50-112-5254


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human IL-23
Biotin-Conjugate anti-human IL-23 monoclonal antibody
Avidin-HRP
Human IL-23 Standard, lyophilized, 4000pg/mL upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Adhesive Films

Description

Description

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 that is disulfide-linked with to two subunits, a p19 subunit unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 interacts with IL-12Rbeta1 and a beta2-like receptor subunit with STAT4 binding domain, IL-23R. IL-23 is secreted by activated mouse and human dendritic cells and is involved in the inflammation process and associated with autoimmune diseases. Mouse IL-23 was found not to induce significant amounts of IFN-gamma, induces strong proliferation of memory T cells (but not naive T cells), and activate mouse memory T cells to produce the proinflammatory cytokine IL-17. On the other hand, human IL-23 induces proliferation of memory T cells, induces moderate levels of IFN-gamma, and is produced by naive and memory T cells. IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance, and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines. IL-23 interacts with the receptors IL-12R beta1 and IL-23R to activate the Jak-Stat signaling cascade. IL-23 has been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.
Specifications

Specifications

Q9NPF7
ELISA
Colorimetric Microplate Reader
ELISA Kit
RUO
Plasma,Serum,Supernatant
Plasma,50 μL|Serum,50 μL|Supernatant,50 μL
2-8°C
3 hr 45 min
IL23A
6.3%
HRP
15.6-2,000 pg/mL
51561
Adhesive Plate Covers
96 tests
4.0 pg/mL
50μL
Human
1 hr 20 min
Human
JKA3 induced upon T cell activation, SGRF
5.9%
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