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Gibco™ Human IL-31 Recombinant Protein, PeproTech®

Catalog No. p-7245940
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Catalog No. Quantity
20031100UG 100 μg
200-31-10UG 10 μg
200-31-1MG 1 mg
200-31-2UG 2 μg
20031500UG 500 μg
200-31-50UG 50 μg
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Catalog No. 20031100UG Supplier Gibco™ Supplier No. 20031100UG
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Description

Recombinant Protein

Recombinant Human IL-31 is a 15.8 kDa protein containing 141 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Interleukin-31 (IL-31) is a recently discovered T-cell cytokine closely related to IL-6 type cytokines and is preferentially produced by T helper type 2 cells. IL-31 activity is mediated through the ligand-induced oligomerization of a dimeric receptor complex containing IL-31 receptor A and oncostatin M receptor. In response to IL-31 binding, these proteins activate the JAK/STAT and the AKT signaling pathways. RNA levels of IL-31 receptor A and oncostatin M receptor are induced in activated monocytes but are expressed constitutively in epithelial cells. IL-31, when overexpressed in transgenic mice, results in the development of pruritis, alopecia, and skin lesions and in humans may result in atopic dermatitis, suggesting that IL-31 may represent a novel target for antipruritic drug development.
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Specifications

Accession Number Q6EBC2
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 386653
Molecular Weight (g/mol) 15.8 kDa
Name Human IL-31
Quantity 100 μg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias 1700013B14Rik; IL31; IL-31; ILN; Interleukin; interleukin 31; interleukin-31
Common Name IL-31
Gene Symbol Il31
Biological Activity Measured by its ability to induce STAT3 activation in human U87 cells.
Conjugate Unconjugated
Recombinant Recombinant
Sequence SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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