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Invitrogen™ Human IL-4 Recombinant Protein

Catalog No. A42602
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Quantity:
5 μg
50 μg
This item is not returnable. View return policy
This item is not returnable. View return policy

Recombinant Protein

Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P05112
For Use With (Application) ELISA, Functional Assay, Immunohistochemistry, Western Blot
Formulation PBS with 0.01% Tween 80, 5% mannitol, 5% trehalose and no preservative; pH 7.4
Gene ID (Entrez) 3565
Molecular Weight (g/mol) 15 kDa
Name Human IL-4
Quantity 5 μg
Source E. coli
Regulatory Status RUO
Gene Alias B cell growth factor 1; B_cell stimulatory factor 1; B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; cytokine; H-IL-4; IGG1 induction factor; IL2; IL4; Il-4; Il4e12; ILN; Interleukin; interleukin 4; interleukin 4 variant 2; interleukin 4 variant IL-4 delta2; interleukin 4 variant IL-4 delta3; interleukin 4 variant IL-4 int2A; interleukin 4 variant IL-4 int3A; interleukin 4 variant IL-4 int3B; Interleukin4; interleukin-4; interleukin-4 precursor; lymphocyte stimulatory factor 1; MGC79402; M-IL-4; Pitrakinra
Common Name IL-4
Gene Symbol Il4
Biological Activity Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.05-0.25 ng/mL
Conjugate Unconjugated
Recombinant Recombinant
Sequence Human IL-4 isoform 1, amino acids His25-Ser153 (Accession # P05112-1) with an N-terminal Met
Content And Storage -20°Cor to +80°C if preferred
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥95 % as determined by SDS-PAGE. ≥95 % as determined by SEC-HPLC.
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WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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