Invitrogen™ Human IRF8 Synthetic Peptide

Catalog No.	Quantity
PEP0206	50 μg

Catalog No. PEP0206 Supplier Invitrogen™ Supplier No. PEP0206

Description

Synthetic Peptide

This peptide corresponds to 16 amino acids near the carboxy terminus of human IRF8. PEP-0206 can be used as a blocking peptide with polyclonal antibody PA5-20088.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.

Specifications

• Gene ID (Entrez): 3394
• Species: Human
• Purification Method: purified
• Accession Number: Q02556
• Common Name: IRF8
• Concentration: 200 μg/mL
• Content And Storage: -20°C
• Description: Synthetic Peptide
• Format: Liquid
• Formulation: PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
• For Use With (Application): Blocking Assay, Control
• Gene Alias: AI893568; H-ICSBP; Icsbp; Icsbp1; IMD32A; IMD32B; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; Interferon regulatory factor 8; Irf8; IRF-8; Myls; transcription factor ICSBP
• Gene Symbol: Irf8
• Lyophilized: No
• Preservative: Sodium azide
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Storage Buffer: PBS