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ACROBiosystems Human LGR5 Protein, His Tag, Low Endotoxin, 1 mg

Catalog No. 502054896
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Human LGR5, also known as GPR49, is a seven-transmembrane protein belonging to the class A Rhodopsin-like family of GPCRs. This protein binds R-spondins with high affinity to mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex promotes Wnt signaling through the neutralization of transmembrane E3 ligases RNF43 and ZNRF3.

  • Expressed from human HEK293 cells, containing amino acids Gly 22 – Arg 561.
  • Carries a polyhistidine tag at the C-terminus.
  • Purity >90% as determined by SDS-PAGE.
  • Endotoxin level <0.01 EU per μg by the LAL/rFC method.
  • Calculated MW of 62.0 kDa; migrates as 65–75 kDa under reducing conditions.
  • Formulated in PBS, pH 7.4 with trehalose as a protectant.

Catalog No. 50-205-4896 Supplier ACROBiosystems Supplier No. LG5H52H31MG
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Human LGR5, also known as GPR49, is a seven-transmembrane protein belonging to the class A Rhodopsin-like family of GPCRs. This protein binds R-spondins with high affinity to mediate the potentiation of Wnt/β-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex promotes Wnt signaling through the neutralization of transmembrane E3 ligases RNF43 and ZNRF3.

  • Expressed from human HEK293 cells, containing amino acids Gly 22 – Arg 561.
  • Carries a polyhistidine tag at the C-terminus.
  • Purity >90% as determined by SDS-PAGE.
  • Endotoxin level <0.01 EU per μg by the LAL/rFC method.
  • Calculated MW of 62.0 kDa; migrates as 65–75 kDa under reducing conditions.
  • Formulated in PBS, pH 7.4 with trehalose as a protectant.

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