Invitrogen™ Human LILRB2 (CD85d, ILT4) Fc Chimera Recombinant Protein

Catalog No.	Quantity
PIRP88127	100 μg

Catalog No. PIRP88127 Supplier Invitrogen™ Supplier No. RP88127

Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (1588 μL) be added to the vial to prepare a stock solution of 0.63 mg/mL. Concentration is measured by UV.

CD85d, also known as LILRB2 or ILT4, is a member of the immunoglobulin-like transcript (ILT), leukocyte Ig-like receptor (LIR), and monocyte Ig-like receptor (MIR) family. It is a 110 kDa single transmembrane receptor with three Ig-like domains and a long cytoplasmic domain containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD85d is expressed on monocytes, macrophages, and dendritic cells. The receptor binds to non-classical class I molecules such as HLA-G, -B, and G1. Upon ligand binding, the tyrosine phosphatase SHP-1 interacts with the ITIMs, transducing a negative signal that inhibits immune response stimulation. This interaction is thought to contribute to tolerance during fetal implantation and plays a role in controlling inflammatory responses and cytotoxicity, helping to focus the immune response and limit autoreactivity. CD85d is also involved in organ allograft rejection, with the levels of ILT3 and ILT4 on dendritic cells suggesting its role in this process. The LILRB2 gene, located in a gene cluster at chromosomal region 19q13.4, encodes multiple transcript variants with different isoforms, highlighting its complexity and importance in immune regulation.

Specifications

• Accession Number: Q8N423
• For Use With (Application): Control, Neutralization
• Format: Lyophilized
• Formulation: PBS with 5% mannitol, 5-8% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
• Gene ID (Entrez): 10288
• Molecular Weight (g/mol): 93 kDa
• Name: Human LILRB2 (CD85d, ILT4) Fc Chimera
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 100 μg
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Endotoxin Concentration: <1.0 EU/μg
• Gene Alias: CD85 antigen-like family member D; CD85D; CD85d antigen; Ig-like transcript 4; ILT4; ILT-4; leucocyte Ig-like receptor B2; leukocyte immunoglobulin like receptor B2; leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; LILRB2; Lilrb3; LIR2; LIR-2; LIR2CD85D; MIR10; MIR-10; MIR10LILRA6; monocyte/macrophage immunoglobulin-like receptor 10; myeloid inhibitory receptor 10; Neutrophil immunoglobulin-like receptor 1; Nilr1; NILR-1; paired-Ig-like receptor B; Pirb; type 1 one-pass transmembrane Ig-like receptor
• Common Name: LILRB2 (ILT4)
• Gene Symbol: LILRB2
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Protein Tag: Fc-tag
• Sequence: Human LILRB2, amino acids Met1-Val461 (Accession # AAH36827.1) with a C-terminal human IgG1 Fc region
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: HEK293 cells
• Form: Lyophilized
• Purity or Quality Grade: >85% as determined by SDS-PAGE.