Invitrogen™ Human LXR alpha (aa 432-442) Synthetic Peptide

Catalog No.	Quantity
PEP115	50 μg

Catalog No. PEP115 Supplier Invitrogen™ Supplier No. PEP115

Description

Synthetic Peptide

PEP-115 is a 14 amino acid synthetic peptide whose sequence corresponds to residues 432-445 of human LXR alpha with an amino-terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): C-L432-R-L-Q-D-K-K-L-P-P-L-L-S-E445 This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human LXR alpha and beta, catalog # PA1-331B. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. Reconstitute with 0.1 mL of distilled water.

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

Specifications

• Gene ID (Entrez): 10062
• Species: Human
• Purification Method: purified
• Accession Number: Q13133
• Common Name: LXR alpha
• Concentration: 0.5 mg/mL
• Content And Storage: -20°C. Avoid freeze-thaw cycles.
• Description: Synthetic Peptide
• Format: Lyophilized
• Formulation: Peptide with no preservative
• For Use With (Application): Control
• Gene Alias: AU018371; liver X nuclear receptor alpha variant 1; liver X receptor alpha; LXR; LXR alpha; Lxra; LXR-a; LXRalpha; LXRb; NER; NERI; NR1H2; Nr1h3; nuclear orphan receptor LXR-alpha; nuclear oxysterol receptor LxR-alpha; nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; oxysterols receptor LXR-alpha; RLD1; RLD-1; ubiquitously-expressed nuclear receptor 1; Unr1
• Gene Symbol: NR1H3
• Lyophilized: Yes
• Preservative: No preservative
• Product Type: Peptide
• Quantity: 50 μg
• Regulatory Status: RUO
• Sequence: C-L432-R-L-Q-D-K-K-L-P-P-L-L-S-E445