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Invitrogen™ Human Ly-108 (aa 152-224) Control Fragment Recombinant Protein

Catalog No. RP101417
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RP101417 100 μL
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Catalog No. RP101417 Supplier Invitrogen™ Supplier No. RP101417
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Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (45%), Rat (45%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62513. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Ly108, the mouse homologue of human SLAMF6 (signaling lymphocyte activation molecule family member 6), is expressed on NK cells, B cells, and T cells. Engagement of the Ly108 receptor enhances NK cell activity and increases the expression of IFN-gamma. This receptor plays a role in the inability of NK cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. In Ly108 knock-out mice, CD4+ T cells show a diminished ability to produce IL-4 and exhibit defective neutrophil functions, indicating the importance of Ly108 in immune regulation and cellular function. Overall, Ly108 is crucial for modulating immune responses and maintaining effective immune cell activity.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q96DU3
Concentration ≥5.0 mg/mL
For Use With (Application) Neutralization, Control
Formulation PBS, 1M urea with no preservative; pH 7.4
Gene ID (Entrez) 114836
Name Human Ly-108 (aa 152-224) Control Fragment
pH Range 7.4
Purification Method Purified
Quantity 100 μL
Storage Requirements -20°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias Activating NK receptor; CD352; KAL1; KAL1b; KALI; KALIb; Ly108; Lymphocyte antigen 108; natural killer-, T- and B-cell antigen; NK-T-B-antigen; NTBA; NTB-A; NTBA receptor; RGD1561848; SF2000; SLAM family member 6; Slamf6; UNQ6123/PRO20080
Common Name Ly-108
Gene Symbol SLAMF6
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-ABP-tag
Sequence TCSVEDADDNVSFRWEALGNTLSSQPNLTVSWDPRISSEQDYTCIAENAVSNLSFSVSAQKLCEDVKIQYTDT
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System E. coli
Form Liquid
Purity or Quality Grade >80% by SDS-PAGE and Coomassie blue staining
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