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Invitrogen™ Human MC4R Synthetic Peptide

Catalog No. PEP0873 Shop All Thermo Scientific Products
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PEP0873 50 μg
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Catalog No. PEP0873 Supplier Invitrogen™ Supplier No. PEP0873
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Description

Synthetic Peptide

This peptide corresponds to 19 amino acids near the amino terminus of human MC4R. PEP-0873 can be used as a blocking peptide with polyclonal antibody PA5-20759.

Expression of MC4R has been reported in brain. Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This 'turn-off' activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
TRUSTED_SUSTAINABILITY

Specifications

Gene ID (Entrez) 4160
Species Human
Purification Method purified
Accession Number P32245
Common Name MC4R
Concentration 200 μg/mL
Content And Storage -20°C
Description Synthetic Peptide
Format Liquid
Formulation PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
For Use With (Application) Blocking Assay, Control
Gene Alias MC4; MC4 receptor; mc4r; Mc4-r; melanocortin 4 receptor; melanocortin receptor 4; si:dkey-151m6.62; zMC4
Gene Symbol MC4R
Lyophilized No
Preservative Sodium azide
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO
Storage Buffer PBS
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