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Invitrogen™ eBioscience™ Human MCP-1 Platinum ELISA Kit Non-distribution product as customer accommodation.

For the quantitative detection of human MCP-1.

Manufacturer:  Invitrogen™ BMS281TEN

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Catalog No. 50-182-28


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human MCP-1
HRP-Conjugate anti-human MCP-1 monoclonal antibody
Human MCP-1 Standard lyophilized, 2ng/mL upon reconstitution
Control high, lyophilized
Control low, lyophilized
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Adhesive Films

Description

Description

MCP-1 (Monocyte chemotactic protein-1, CCL2) has a predicted molecular weight of approximately 11kDa, however, it may run at a higher molecular weight due to glycosylation. MCP-1 is a member of the cytokine family and plays an important role in immunoregulation and inflammatory processes. MCP-1 signals through G protein-coupled receptors, CCR2 and CCR4, to recruit memory T cells, monocytes and dendritic cells. MCP-1 is linked with tumor progression, angiogenesis, and displays selective chemotactic activity towards monocytes and basophils but not neutrophils or eosinophils. MCP-1 is produced by a variety of cell types and is a potent chemoattractant for monocytes, memory T lymphocytes, and natural killer (NK) cells. Further, MCP-1 is indicated in the etiology of several immune disorders, and is upregulated during infection and inflammation. While MCP-1 is a potent basophil activator, the related protein MCP-2 stimulates both eosinophils and basophils. MCP-3 has been shown to have the broadest range of influence. MCP-1 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis.
Specifications

Specifications

P13500
HRP
6347
Adhesive Plate Covers
10 x 96 tests
2.3 pg/mL
20μL
Human
1 hr 20 min
Human
Monocyte chemoattractant protein 1, MCAF, HC11
4.7%
15.6-1,000 pg/mL
ELISA
Colorimetric Microplate Reader
ELISA
RUO
Amniotic Fluid, Plasma, Serum, Supernatants
Amniotic Fluid (20μL), Plasma (20μL), Serum (20μL), Supernatants (20μL)
2-8°C
2 hr 10 min
CCL2
8.7%
HRP
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