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BioVendor, LLC MMP-9 Human, Mouse Monoclonal Antibody, Clone: S22.2 (100 ug)
Supplier: BioVendor, LLC QZBMMP9S22.2100
MMP-9 Human, Mouse Monoclonal Antibody, Clone: S22.2 (100 ug). Manufactured by QuickZyme Biosciences. Mouse MAb against recombinant human MMP-9. Also reacts with mouse and rabbit MMP-9. No cross reactivity observed with human MMP-1, MMP-2, MMP-3, MMP-8, TIMP-1, TIMP-2. Formulation: in PBS containing 0.1% w/v BSA. Applications: Western blotting, ELISA, IHC. Synonyms: Matrix metalloproteinase-9, MMP9, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB. MMP-9 Summary: May play essential role in local proteolysis of the ECM and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal 3/4 fragments and shorter N-terminal 1/4 fragments. Degrades fibronectin but not laminin or Pz-peptide. In arthritis patients this enzyme might contribute to the pathogenesis of joint destruction. A significant positive correlation has been found between tissue MMP9 and the stage of colorectal tumours at diagnosis.
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