Invitrogen eBioscience Human/Mouse TGF beta 1 ELISA Ready-SET-Go! Kit, 2nd Generation
Specifically engineered for accurate and precise measurement of human or mouse TGF beta 1 protein levels from samples including serum, plasma, and cell culture supernatants. This second generation kit has increased sensitivity with a range of 8-1000pg/mL.
Manufacturer: Invitrogen 88835022
DescriptionTGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
|96-well Plates: Corning Costar flat-bottom plates (included with Cat. Nos. ending in -22; -76; and -86)|
|2 x 96 tests|
|Plasma,20 μL|Serum,20 μL|Supernatant,100 μL|
|24 hr 30 min|
|Colorimetric Microplate Reader|
|1 hr 45 min|
|Transforming Growth Factor beta 1, TGF-b1|
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