Invitrogen™ Human NABP1 (aa 1-20) Control Fragment Recombinant Protein

Catalog No.	Quantity
RP107598	100 μL

Catalog No. RP107598 Supplier Invitrogen™ Supplier No. RP107598

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (70%), Rat (70%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66952. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

NABP1, also known as NABP1/Ssb2, is a single-stranded DNA-binding protein involved in genome maintenance and stability. The gene encoding NABP1 is regulated by RORgamma2, a retinoid-related orphan receptor critical for thymopoiesis. Research has demonstrated that NABP1 plays a compensatory role in thymic maturation, particularly in conditions where its homolog, SSB1, is knocked out. Despite SSB1's vital role in neonatal survival, NABP1 remains non-essential for thymic maturation and male fertility, indicating partial functional redundancy between these proteins. Furthermore, studies on the C-terminal regions of NABP1 have shown distinct roles in nucleic acid binding, contributing to DNA and RNA metabolism. These findings highlight NABP1's importance in genomic integrity and its complex interplay within cellular processes.

Specifications

• Accession Number: Q96AH0
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Neutralization, Control
• Formulation: PBS, 1M urea with no preservative; pH 7.4
• Gene ID (Entrez): 64859
• Name: Human NABP1 (aa 1-20) Control Fragment
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 100 μL
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: 4930434H03Rik; 4930442A21Rik; 4930488J04Rik; 4933440J18Rik; 5830411E10Rik; AI852561; hSSB2; Nabp1; Nbp1; nucleic acid binding protein 1; nucleic acid-binding protein 1; Obfc2a; oligonucleotide/oligosaccharide-binding fold containing 2A; oligonucleotide/oligosaccharide-binding fold-containing protein 2A; RGD1306658; Sensor of single-strand DNA complex subunit B2; sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2; SOSS complex subunit B2; SOSS-B2; Ssb2
• Common Name: NABP1
• Gene Symbol: NABP1
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: MNRVNDPLIFIRDIKPGLKN
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining