Gibco™ Human NKG2D Fc Recombinant Protein, PeproTech®

Catalog No.	Quantity
50-003-31936	500 μg
50-003-31921	100 μg
31-051-10UG	10 μg
31-051-1MG	1 mg
50-003-31935	250 μg
31-051-50UG	50 μg

Catalog No. 50-003-31936 Supplier Gibco™ Supplier No. 31051500UG

Description

Recombinant Protein

Recombinant Human NKG2D Fc is an 84.8 kDa glycosylated, disulfide-linked homodimer whose 374 amino acid monomer consists of the 139 amino acid N-terminal portion of the extracellular domain fused to the 233-amino-acid residue C-terminal Fc region of human IgG by two glycine residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis.

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can regulate specific humoral and cell-mediated immunity, and preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NK gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.

Specifications

• Accession Number: P26718
• For Use With (Application): Binding Assay, Bioactivity
• Formulation: Protein with no preservative
• Gene ID (Entrez): 22914
• Molecular Weight (g/mol): 42.4 kDa
• Name: Human NKG2D Fc
• Purification Method: Purified
• Quantity: 500 μg
• Storage Requirements: -20°C
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/μg
• Gene Alias: CD314; D12S2489E; D6H12S2489E; killer cell lectin like receptor K1; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; KLR; Klrk1; natural killer cell group 2D; natural killer cell receptor; NK cell receptor D; NK lectin-like receptor; Nkg2d; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKLLR; Nkrp2; NKR-P2; NKR-P2, ortholog of human NKG2D
• Common Name: NKG2D (CD314)
• Gene Symbol: Klrk1
• Product Type: Protein
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Protein Tag: Fc-tag
• Sequence: MDPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGKGGFLNSL FNQEVQIPLT ESYCGPCPKN WICYKNNCYQ FFDESKNWYE SQASCMSQNA SLLKVYSKED QDLLKLVKSY HWMGLVHIPT NGSWQWEDGS ILSPNLLTII EMQKGDCALY ASSFKGYIEN CSTPNTYICM QRTV
• Activity: Determined by its ability to bind human MICA/Fc Chimera in a functional ELISA.
• Expression System: CHO cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.