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Invitrogen™ eBioscience™ Human PAI-1 Platinum ELISA Kit Non-distribution product as customer accommodation.

For the quantitative detection of human PAI-1.

Manufacturer:  Invitrogen™ BMS2033

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Catalog No. 50-112-5262


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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human PAI-1
Biotin-Conjugate anti-human PAI-1 polyclonal antibody
Streptavidin-HRP
Human PAI-1 Standard lyophilized, 10000pg/mL upon reconstitution
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

PAI1 (plasminogen activator inhibitor 1) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). Platelets are the main source of the circulating PAI11, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells. Expression of PAI11 can be regulated at the transcriptional level by many factors including growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors. PAI1 is present at increased levels in various disease states, and has been linked to an increased occurrence of thrombosis in obesity, thrombophilia and the metabolic syndrome. Defects in PAI-1 are characterized by abnormal bleeding. PAI1 mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator, and may promote neuronal survival. Other defects in PAI1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency). Alternatively spliced transcript variants encoding different isoforms of PAI1 have been found.
Specifications

Specifications

P05121
Biotin
5054
Adhesive Plate Covers
96 tests
29.0 pg/mL
50μL (1:50 prediluted)
Human
1 hr 20 min
Human
Serpin peptidase inhibitor, PAI-E, PLANH1
4.7%
78-5,000 pg/mL
ELISA
Colorimetric Microplate Reader
ELISA Kit
RUO
Plasma,Serum,Supernatant
Plasma,10 μL|Serum,10 μL|Supernatant,10 μL
2-8°C
3 hr 10 min
SERPINE1
5%
HRP
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