Invitrogen™ Human PITX2 (aa 244-271) Control Fragment Recombinant Protein

Catalog No.	Quantity
RP107189	100 μL

Catalog No. RP107189 Supplier Invitrogen™ Supplier No. RP107189

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66524. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

Specifications

• Accession Number: Q99697
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Neutralization, Control
• Formulation: PBS, 1M urea with no preservative; pH 7.4
• Gene ID (Entrez): 5308
• Name: Human PITX2 (aa 244-271) Control Fragment
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 100 μL
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: 9430085M16Rik; all1-responsive gene 1; ALL1-responsive protein ARP1; Arp1; Brx1; BRX1 homeoprotein; Brx1b; Homeobox protein PITX2; homeodomain transcription factor 2; IDG2; IGDS; IGDS2; IHG2; IRID2; Munc30; orthodenticle-like homeobox 2; Otlx2; paired like homeodomain 2; paired like homeodomain transcription factor 2; paired-like homeodomain 1; paired-like homeodomain 2; paired-like homeodomain transcription factor 1; paired-like homeodomain transcription factor 2; paired-like homeodomain transcription factor 2c; paired-like homeodomain transcription factor Munc 30; Pituitary homeobox 2; PITX1; Pitx2; Pitx-2; Pitx2c; Ptx2; Rgs; Rieg; RIEG bicoid-related homeobox transcription factor; rieg bicoid-related homeobox transcription factor 1; RIEG1; rPtx2; RS; S a 1 glycoprotein; S a1glycoprotein; S alpha 1 glycoprotein; S α 1 glycoprotein; S α1glycoprotein; Solurshin
• Common Name: PITX2
• Gene Symbol: PITX2
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: NLNNLSSPSLNSAVPTPACPYAPPTPPY
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining