Invitrogen™ Human PKM2 Recombinant Protein

Catalog No.	Quantity
PIRP75744	1 mg

Catalog No. PIRP75744 Supplier Invitrogen™ Supplier No. RP75744

Description

Recombinant Protein

This product contains purified recombinant full length human PKM2 Pyruvate Kinase protein with an N-terminal hexahistidine tag. This product may be used as a positive control in many immunological assays.

PKM2 is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. PKM2 has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. PKM2 has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms of PKM2 have been reported.

Specifications

• Accession Number: P14618
• Concentration: 0.295 mg/mL
• For Use With (Application): Control, Western Blot
• Formulation: PBS with 50% glycerol and no preservative; pH 7.4
• Gene ID (Entrez): 5315
• Name: Human PKM2
• pH Range: 7.4
• Quantity: 1 mg
• Source: E. coli
• Immunogen: N/A
• Regulatory Status: RUO
• Gene Alias: AA414905; AL024370; AL024424; ATP:pyruvate 2-o-phosphotransferase; CTHBP; Cytosolic thyroid hormone-binding protein; epididymis secretory protein Li 30; HEL-S-30; isozymes M1/M2; m2pk; muscle pyruvate kinase; OIP3; OIP-3; OPA-interacting protein 3; p58; Pk., muscle type; PK2; Pk.-2; Pk3; Pk.-3; PKLR; PKM; pkm.L; PKM12; PKM2; Pykm; pyruvate kinase; pyruvate kinase 2/3; pyruvate kinase 3; pyruvate kinase isozymes M1/M2; pyruvate kinase M1/2; pyruvate kinase M1/2 L homeolog; pyruvate kinase M1/2 L homeolog; pyruvate kinase, muscle; pyruvate kinase muscle isozyme; Pyruvate kinase PKM; pyruvate kinase, liver and RBC; pyruvate kinase, muscle; TCB; THBP1; thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; tu; tumor M2-Pk.; XELAEV_18018020mg
• Common Name: PKM2
• Gene Symbol: PKM
• Conjugate: Unconjugated
• Species: E. coli
• Recombinant: Recombinant
• Protein Tag: His-tag
• Sequence: Amino acids Met1-Pro531 containing an N-terminal His-tag
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Protein Subtype: Recombinant
• Purity or Quality Grade: >95%, by SDS-PAGE under reducing conditions