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Gibco™ Human Plateable Hepatocytes, Metabolism Qualified
Description
These cryopreserved human hepatocytes are suitable for use in plated metabolism applications.
Cells per vial: 4-8 million
Prototypical cytochrome P450 substrates midazolam, tolbutamide, and dextromethorphan were used to assess the enzymatic function of CYP3A4⁄5, CYP2C9 and CYP2D6 respectively. The disappearance of parent was monitored by LC-MS⁄MS analysis and intrinsic clearance (CLint) values determined by linear regression.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
Phase I and II enzyme activities
Proper morphology
Viabilities generally >75%
Attachment efficiency
Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Prototypical cytochrome P450 substrates midazolam, tolbutamide, and dextromethorphan were used to assess the enzymatic function of CYP3A4⁄5, CYP2C9 and CYP2D6 respectively. The disappearance of parent was monitored by LC-MS⁄MS analysis and intrinsic clearance (CLint) values determined by linear regression.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Specifications
Specifications
| Content And Storage | Store in a cryostorage dewar or -135°C freezer. |
| Cell Type | Hepatocytes |
| Culture Type | Mammalian Cell Culture |
| Form | Cryopreserved |
| Species | Human |
| Donor Source | Single Donor |
| No. of Cells | 4-8 x 106 |
| Product Line | Gibco |
| Product Type | Hepatocytes |
| Quantity | 1.5 mL |
Safety and Handling
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
For Research Use Only. Not for use in diagnostic procedures.
Product Title
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