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Gibco™ Human Plateable Hepatocytes, Transporter Qualified
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Quantity:
1.5 mL vial
Description
Plateable cryopreserved human hepatocytes assessed for transporter function using uptake transporter assays at both 4°C and 37°C.
Cells per vial: 4-8 million
Hepatocyte cultures were incubated with radiolabeled taurocholate, digoxin, and estradiol 17β glucuronide (E2-17G), substrates of the uptake and efflux transporters NTCP and BSEP, OCT1 and MDR1, and OATPs and MRP2, respectively. Accumulation rates and biliary excretion index (BEI%) were calculated.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
Phase I and II enzyme activities
Proper morphology
Viabilities generally >75%
Attachment efficiency
Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Hepatocyte cultures were incubated with radiolabeled taurocholate, digoxin, and estradiol 17β glucuronide (E2-17G), substrates of the uptake and efflux transporters NTCP and BSEP, OCT1 and MDR1, and OATPs and MRP2, respectively. Accumulation rates and biliary excretion index (BEI%) were calculated.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Specifications
Specifications
| Content And Storage | Store in a cryostorage dewar or -135°C freezer. |
| Cell Line | Primary |
| Cell Type | Hepatocytes |
| Culture Type | Hepatocyte Cell Culture |
| Form | Cryopreserved |
| Species | Human |
| Tissue | Liver |
| Donor Source | Single Donor |
| No. of Cells | 4-8 x 106 |
| Product Line | Gibco™ |
| Show More |
For Research Use Only. Not for use in diagnostic procedures.
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