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Gibco™ Human Plateable Hepatocytes, Uptake Qualified
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Quantity:
1.5 mL
Description
Cryopreserved human hepatocytes for use in transporter-mediated uptake applications.
Cells per vial: 4-8 million
Prototypical hepatic uptake transporter substrates taurocholate and estradiol-17β-glucuronide have been assessed to qualify the transport function of hepatic NTCP (SLC10A1) and OATP1B14/3 (SLCO1B1/3), respectively. The transport of each substrate (radiolabeled) was monitored by scintillation analysis and active transport values (37°C - 4°C) determined by linear regression.
Get the Results You Need with GIBCO™ Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
Phase I and II enzyme activities
Proper morphology
Viabilities generally >75%
Attachment efficiency
Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Link
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes
Cells per vial: 4-8 million
Prototypical hepatic uptake transporter substrates taurocholate and estradiol-17β-glucuronide have been assessed to qualify the transport function of hepatic NTCP (SLC10A1) and OATP1B14/3 (SLCO1B1/3), respectively. The transport of each substrate (radiolabeled) was monitored by scintillation analysis and active transport values (37°C - 4°C) determined by linear regression.
Get the Results You Need with GIBCO™ Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Link
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes
Specifications
Specifications
| Cell Passage Number | Passage 0 |
| Content And Storage | Vials of cryopreserved hepatocytes should be stored in a cryostorage dewar or -135°C freezer. |
| Cell Type | Hepatocytes |
| Culture Type | Adherent Cell Culture |
| Form | Cryopreserved |
| Species | Human |
| Donor Source | Single Donor |
| Format | Tube |
| No. of Cells | 4-8 x 106 |
| Product Line | Gibco™ |
| Show More |
For Research Use Only. Not for use in diagnostic procedures.
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