Invitrogen™ Human POM121 (aa 46-100) Control Fragment Recombinant Protein

Catalog No.	Quantity
RP99569	100 μL

Catalog No. RP99569 Supplier Invitrogen™ Supplier No. RP99569

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (70%), Rat (70%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-83681. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

POM121 (POM121 membrane glycoprotein), also known as POM121A (nuclear envelope pore membrane protein POM 121A), NUP121 (nucleoporin Nup121) or pore membrane protein of 121 kDa, is a 1,249 amino acid single-pass membrane protein that exists as three alternatively spiced isoforms and belongs to the POM121 family. Encoded by a gene that maps to human chromosome 7q11.23, POM121 is highly conserved and localizes to nucleus membrane and endoplasmic reticulum membrane. An essential component of the nuclear pore complex (NPC), POM121 is mandatory for nuclear envelope formation and may play a role in biogenesis of the NPC. POM121 associates with the central spoke ring complex and is involved in anchoring components of the pore complex to the pore membrane by way of its F-X-F-G repeat-containing domain. POM121 overexpression induces the formation of cytoplasmic annulate lamellae (AL).

Specifications

• Accession Number: A6NF01, A8CG34, Q96HA1
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Neutralization, Control
• Formulation: PBS, 1M urea with no preservative; pH 7.4
• Gene ID (Entrez): 100101267, 100288540, 9883
• Name: Human POM121 (aa 46-100) Control Fragment
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 100 μL
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: 2610027A18Rik; C80273; KIAA0618; mKIAA0618; Nuclear envelope pore membrane protein POM 121; nuclear envelope pore membrane protein POM 121A; nuclear envelope pore membrane protein POM 121C; nuclear pore membrane glycoprotein 121 kD; nuclear pore membrane protein 121; nuclear pore membrane protein 121 kDa; nuclear pore membrane protein 121-2; nucleoporin Nup121; Nup121; p145; Pom121; POM121 membrane glycoprotein; POM121 membrane glycoprotein C; POM121 transmembrane nucleoporin; POM121 transmembrane nucleoporin C; POM121-2; POM121A; POM121B; POM121C; Pore membrane protein of 121 kDa; pore membrane protein of 121 kDa C
• Common Name: POM121
• Gene Symbol: POM121, POM121B, POM121C
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: HHSSSSTPLAADKESQGEKAADTTPRKKQNSNSQSTPGSSGQRKRKVQLLPSRRG
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining