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  5. Invitrogen™ Human Presenilin 2 ELISA Kit 

Invitrogen™ Human Presenilin 2 ELISA Kit

Catalog No. EH381RBX5
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EH381RB 96 Tests
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Description

ELISA

Human Presenilin 2 quantitates human Presenilin 2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Presenilin 2.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number AD3L; AD3LP; AD4; Ad4h; AD5; Alg3; ALG-3; Alzheimer disease 4; CMD1V; E5-1; presenilin 2; presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS2; Ps-2; PSEN 2; Psen2; Psnl2; STM2; STM-2
Assay Range 0.2 to 50 ng/mL
Assay Sensitivity 0.2 ng/mL
Conjugate HRP
Product Type ELISA
Sample Type Plasma, Serum, Supernatant
For Use With (Equipment) Colorimetric Microplate Reader
Gene ID (Entrez) 5664
Gene Symbol PSEN2
Interassay CV <12%
Intraassay CV <10
Kit Contents Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
Label or Dye HRP
Quantity 5 x 96 Tests
Regulatory Status RUO
Sample Volume Plasma 50 μL, Serum 50 μL, Supernatant 50 μL
Storage Requirements 2°C to 8°C
Target PSEN2
Test Time 1 hrs 20 mins
Total Assay Time 4 hrs 45 mins
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