Invitrogen™ Human PRPS2 Control Fragment Recombinant Protein

Catalog No.	Quantity
RP105432	100 μL

Catalog No. RP105432 Supplier Invitrogen™ Supplier No. RP105432

Description

Recombinant Protein

Highest antigen sequence indentity to the following orthologs: Mouse (40%), Rat (40%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66936. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

The Phosphoribosyl Pyrophosphate Synthetase 2 (PRPS2) gene plays a critical role in cellular metabolism by encoding an enzyme that conducts a key reaction linking central carbon metabolism and nucleotide production, essential for various biological functions. Structurally, PRPS2 shares a high sequence identity with PRPS1, making it less sensitive to allosteric inhibition and particularly significant in certain oncology contexts due to its upregulation at the translational level in some cancers. The enzyme encoded by PRPS2 is pivotal in coupling protein and nucleotide biosynthesis, aided by a unique cis-regulatory element in its 5' UTR, which is influenced by oncogenic pathways. This gene manifests a tissue-specific expression profile, predominantly in proliferative tissues such as the thymus, lung, and small intestine, highlighting its significance in cell growth and proliferation. The evolutionary origins of PRPS2, along with its functional diversification into multiple PRPS genes in eukaryotes, underscore its indispensable role in cellular physiology and pathology.

Specifications

• Accession Number: P11908
• Concentration: ≥5.0 mg/mL
• For Use With (Application): Neutralization, Control
• Formulation: PBS, 1M urea with no preservative; pH 7.4
• Gene ID (Entrez): 5634
• Name: Human PRPS2 Control Fragment
• pH Range: 7.4
• Purification Method: Purified
• Quantity: 100 μL
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Gene Alias: 2610101M19Rik; AA589463; AI464149; Phophoribosylpyrophosphate synthetase, subunit II; phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase 2; phosphoribosyl pyrophosphate synthetase II; PPRibP; PPRibP synthetase; Prps2; Prps-2; PRSII; PRS-II; ribose-phosphate diphosphokinase 2; ribose-phosphate pyrophosphokinase 2; testicular secretory protein Li 41
• Common Name: PRPS2
• Gene Symbol: PRPS2
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: His-ABP-tag
• Sequence: GAKRYHAGYTLQISPSADWF
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Expression System: E. coli
• Form: Liquid
• Purity or Quality Grade: >80% by SDS-PAGE and Coomassie blue staining