Gibco™ Human R-Spondin-3 Recombinant Protein, PeproTech®

Catalog No.	Quantity
12044100UG	100 μg
120-44-1MG	1 mg
120-44-20UG	20 μg
12044250UG	250 μg
12044500UG	500 μg
120-44-5UG	5 μg

Catalog No. 12044100UG Supplier Gibco™ Supplier No. 12044100UG

Description

Recombinant Protein

Recombinant Human R-Spondin-3 is a 26.9 kDa protein consisting of 240 amino acid residues. Due to glycosylation, R-Spondin-3 migrates at an apparent molecular weight of approximately 37.0 kDa by SDS PAGE analysis under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

RSPO3 is a member of the R-spondin family and plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. RSPO3 has been shown to be involved in regulating the balance between angioblast and blood cell specification during embryonic vasculogenesis and angiogenesis and may be involved in tumor development.

Specifications

• Accession Number: Q9BXY4
• For Use With (Application): Functional Assay
• Formulation: protein with no preservative
• Gene ID (Entrez): 84870
• Molecular Weight (g/mol): 26.9 kDa
• Name: Human R-Spondin-3
• Quantity: 100 μg
• Source: CHO cells
• Regulatory Status: RUO
• Endotoxin Concentration: <1 EU/ μg
• Gene Alias: 2810459H04Rik; AW742308; Cabriolet; cristin 1; Cristin1; cristin-1; cysteine-rich and single thrombospondin domain-containing protein 1; hPWTSR; hRspo3; Nucleopondin; protein with TSP type-1 repeat; PWTSR; RGD1563246; Roof plate-specific spondin-3; Rspo3; R-spondin 3; R-spondin 3 homolog; R-spondin 3 homolog (Xenopus laevis); R-spondin 3-like protein; R-spondin-3; Thrombospondin type-1 domain-containing protein 2; thrombospondin, type I, domain 2; thrombospondin, type I, domain containing 2; Thsd2; Unknown (protein for MGC:137973)
• Common Name: RSPO3
• Gene Symbol: RSPO3
• Biological Activity: R-Spondin-3 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The expected ED50 for this effect is 0.8 -2.0 ug/ml
• Conjugate: Unconjugated
• Recombinant: Recombinant
• Sequence: MHPNVSQGCQ GGCATCSDYN GCLSCKPRLF FALERIGMKQ IGVCLSSCPS GYYGTRYPDI NKCTKCKADC DTCFNKNFCT KCKSGFYLHL GKCLDNCPEG LEANNHTMEC VSIVHCEVSE WNPWSPCTKK GKTCGFKRGT ETRVREIIQH PSAKGNLCPP TNETRKCTVQ RKKCQKGERG KKGRERKRKK PNKGESKEAI PDSKSLESSK EIPEQRENKQ QQKKRKVQDK QKSVSVSTVH
• Content And Storage: -20°C
• Expression System: CHO cells
• Form: Lyophilized
• Purity or Quality Grade: ≥ 95% by SDS-PAGE gel and HPLC analyses.