Gibco™ Human/Rat Neuritin Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Supplier:  Gibco™ 45036D20UG

Catalog No. 45036D20UG

Description

As the nervous system of a complex organism develops, it establishes functional networks through the growth and retraction of synaptic connections from growing axons and dendrites. This synaptic remodeling involves neuro-transmitter signaling, activation of neurotrophin receptors and alterations in gene expression. One such gene whose expression is increased by neural activity is neuritin, a GPI-anchored protein that is expressed in postmitotic differentiating neurons of the developing nervous system. Its expression is also induced by the neurotrophins BDNF and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic neuronal cultures, suggesting that neuritin may play a role as a downstream effector of activity-induced neurite outgrowth. More recent experiments have shown that neuritin is required for the androgen-induced axonal elongation in motor neurons and is upregulated following spinal cord injury, suggesting that neuritin may also play a role in survival and axonal regeneration.

Specifications

• Accession Number: O08957, Q9NPD7
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 19.4
• Quantity: 20 μg
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: NRN1
• Conjugate: Unconjugated
• Sequence: AGKCDAVFKG FSDCLLKLGD SMANYPQGLD DKTNIKTVCT YWEDFHSCTV TALTDCQEGA KDMWDKLRKE SKNLNIQGSL FELCGSGN
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.

• For Use With (Application): Functional Assay
• Gene ID (Entrez): 51299, 83834
• Name: Human/Rat Neuritin
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: 0710008J23Rik; Candidate plasticity gene 15 protein; candidate plasticity-related gene 15; Cpg15; dJ380B8.2; Neuritin; neuritin 1; NRN; NRN1
• Specific Reactivity: Human, Rat
• Recombinant: Recombinant
• Form: Lyophilized