STEMCELL Technologies Human Recombinant IL-2, ACF, Size: 1000 µg

Supplier:  STEMCELL Technologies 78145.2

Use interleukin 2 (IL-2) to modulate cellular proliferation and survival through JAK3, STAT5, and AKT pathways (Ma et al. Annu Rev Immunol, 2006). IL-2 is a monomeric cytokine that binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. IL-2 downregulates immune responses during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. It also controls inflammation by inhibiting Th17 differentiation (Banchereau et al. Nat Immunol, 2012). High IL-2 levels are associated with progression of scleroderma, rheumatoid arthritis, gastric and non-small cell lung cancer, but no known disease is attributed to the lack or excess of IL-2 (Gaffen & Liu. Cytokine, 2004). Human recombinant IL-2 from STEMCELL is animal component-free and comes lyophilized with ≥ 95% purity; EC50 ≤ 3 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: Aldesleukin, Interleukin-2, T cell growth factor, TCGF.

Catalog No. NC1745930