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STEMCELL Technologies Human Recombinant EGF, ACF, Size: 500 ug
Supplier: STEMCELL Technologies 78136.1
Epidermal growth factor (EGF) is characterized by high-affinity binding to various EGF receptors (EGFRs) and the production of mitogenic responses (Carpenter Cohen). EGF promotes EGFR dimerization resulting in activation of downstream pathways including PI3K ERK1/2 JAK/STAT -catenin and calcium signaling. EGF is secreted by the gut-associated salivary and Brunner’s glands is found in a variety of body fluids and stimulates cell proliferation and differentiation in rodent and neonatal human intestine (Wright et al.). Central nervous system stem cells also proliferate in response to the EGF stimulus (Reynolds Weiss). This product is animal component-free.
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