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STEMCELL Technologies Human Recombinant FGF-7, ACF, Size: 1000 ug
Supplier: STEMCELL Technologies 78186.2
Fibroblast growth factor 7 (FGF-7) is a member of the FGF family and acts exclusively through a subset of FGF receptor isoforms expressed predominantly by epithelial cells (Finch Rubin). FGF-7 seems to act specifically on epithelial cells and stimulates proliferation migration and differentiation of these cells and also participates in epithelial protection and repair both in vitro and in vivo (Finch Rubin Werner). In contrast FGF-7 is produced solely by cells of mesenchymal origin and functions as a paracrine mediator of mesenchymal-epithelial communication (Rubin et al.). FGF-7 has also been shown to supplement several wound-healing properties of bioengineered skin (Erdag et al.) and to induce autophagy in human keratinocytes (Belleudi et al.). Additionally FGF-7 has a role in the differentiation of pluripotent stem cell to endodermal pancreatic-like insulin-producing cells and thymic epithelial
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