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STEMCELL Technologies Human Recombinant FGF-8A, Size: 1000 ug
Supplier: STEMCELL Technologies 78128.2
Fibroblast growth factor 8A (FGF-8A) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. FGF-8A binds the FGF receptor (FGFR) and activates Ras/MAPK signaling (Hulstrand Houston). The FGF family possesses broad mitogenic and cell survival activities (Folkman Klagsbrun Kimelman Kirschner) and is involved in a variety of biological processes including cell proliferation differentiation survival and apoptosis (Folkman Klagsbrun Klagsbrun Rifkin Moscatelli). FGF-8 RNA is spliced to produce 4 protein isoforms in humans FGF-8A FGF-8B FGF-8E and FGF-8F. The functional differences are not fully understood however studies in zebrafish and Xenopus show that FGF-8A is required for endoderm morphogenesis and neurogenesis (Choe Crump Hulstrand Houston).
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