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STEMCELL Technologies Human Recombinant GDNF, Size: 1000 µg
Supplier: STEMCELL Technologies 78058.2
Use glial cell line-derived neurotrophic factor (GDNF) to promote the survival and morphological differentiation of midbrain dopaminergic neurons (Granholm et al. J Neurosci, 2000). GDNF is a neurotrophic factor and a member of the tumor growth factor (TGF)-beta superfamily. The GDNF family ligands signal through binding to specific GDNF-family receptor-α co-receptors, activating the RET receptor tyrosine kinase (Durbec et al. Nature, 1996). GDNF, together with Human Recombinant BDNF (Catalog #78005), BrainPhys™ Neuronal Medium (Catalog #05790), and other supplements, can be used to differentiate human pluripotent stem cell-derived neural progenitor cells into neurons (Bardy et al. Proc Natl Acad Sci USA, 2015). Human recombinant GDNF from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 3 μg/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: Astrocyte-derived trophic factor, ATF, ATF1, ATF2, Glial cell-derived neurotrophic factor.
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