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STEMCELL Technologies Human Recombinant IL-10, ACF, Size: 100 ug
Supplier: STEMCELL Technologies 78144.1
Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines. All of the IL-10 cytokine family members have a four-helix bundle consisting of a-helical folds. Upon binding to its receptor IL-10 activates signaling through JAK1 and STAT3. It is produced by dendritic cells macrophages and CD4 T cells as well as mast cells NK cells neutrophils and B cells under specific stimulating conditions (Saraiva O'Garra). IL-10 can inhibit the expression of pro-inflammatory cytokines and promote healing processes and is important for the function of T regulatory cells. IL-10 also enhances B cell proliferation immunoglobulin secretion and class II MHC expression while IL-10 produced by macrophages inhibits activation of neighboring macrophages thus allowing a level of self-regulation (Ouyang et al.). This product is animal component-free.
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