STEMCELL Technologies Human Recombinant IL-2 (CHO-expressed), Size: 50 µg

Supplier:  STEMCELL Technologies 78036

Use interleukin 2 (IL-2) to modulate cellular proliferation and survival through JAK3, STAT5, and AKT signaling pathways (Ma et al. Annu Rev Immunol, 2006). IL-2 is a monomeric cytokine that binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. IL-2 downregulates immune responses during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. It also controls inflammation by inhibiting Th17 differentiation (Banchereau et al. Nat Immunol, 2012). High IL-2 levels are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen & Liu. Cytokine, 2004). Human recombinant IL-2 from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 2 ng/mL; endotoxin levels verified ≤ 0.2 EU/μg protein. Alternative names: Aldesleukin, Interleukin-2, T cell growth factor, TCGF.

Catalog No. NC1270616

Safety and Handling

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