STEMCELL Technologies Human Recombinant IL-2 (E. coli-expressed), Size: 100 µg

Supplier:  STEMCELL Technologies 78220.1

Use interleukin 2 (IL-2) to modulate cellular proliferation and survival through JAK3, STAT5, and AKT signaling pathways (Ma et al. Annu Rev Immunol, 2006). IL-2 is a monomeric cytokine that binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. IL-2 downregulates immune responses during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. It controls inflammation by inhibiting Th17 differentiation (Banchereau et al. Nat Immunol, 2012). High IL-2 levels are linked with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer but no known disease can be directly linked to the lack or excess of IL-2 (Gaffen & Liu. Cytokine, 2004). Human recombinant IL-2 (E. coli-expressed) from STEMCELL comes lyophilized with ≥ 95% purity; EC50 ≤ 3 ng/mL; endotoxin levels verified ≤ 1 EU/μg protein. Alternative names: Aldesleukin, Interleukin-2, T cell growth factor, TCGF.

Catalog No. 50-197-6776